COVERAGE France: A French national adaptative platform trial to evaluate outpatient treatments against COVID-19

Topic:
COVID-19

Sponsor:
Bordeaux University Hospital

Funder:
French Ministry of Health and labeled France National Research Priority

Description

COVERAGE trial was a multicentric adaptative randomized controlled clinical trial plateform evaluating several treatment strategies against COVID19 in outpatients with aggravating risk factors. The dissemination of the Coverage trial is currently underway.

Role of EUCLID

Methodology
Statistical aspects
Data management
Global coordination of the trial

Publications

Duvignaud, A., Lhomme, E., Pistone, T. et al. Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial). Trials 21, 846 (2020).

Alexandre Duvignaud, Edouard Lhomme, Racha Onaisi, Rémi Sitta, Ambre Gelley, Julie Chastang, Lionel Piroth, Christine Binquet, Julie Dupouy, Alain Makinson , Benjamin Lefèvre, Jean-Marc Naccache, Caroline Roussillon, Roland Landman, Cédrick Wallet, Sophie Karcher, Valérie Journot, Duc Nguyen, Thierry Pistone, Stéphane Bouchet, Marie-Edith Lafon, Mathieu Molimard, Rodolphe Thiébaut, Xavier de Lamballerie, Jean-Philippe Joseph, Laura Richert, Olivier Saint-Lary, Sarah Djabarouti, Linda Wittkop, Xavier Anglaret, Denis Malvy ; Coverage Study Group. Inhaled ciclesonide for outpatient treatment of COVID-19 in adults at risk of adverse outcomes: a randomised controlled trial (COVERAGE). 2022. Clinical Microbiology and Infection. 28. 00108-2.

Rodolphe Thiébaut, Edouard Lhomme, Hakim Hocini, Isabelle Pellegrin, Andrea Boizard-Moracchini, Alexandre Duvignaud, Maud Perpère, Mélanie Huchon, Mélanie Prague, Christine Lacabaratz, Mathieu Surenaud, Xavier Anglaret, Denis Malvy, Boris P. Hejblum, Yves Levy, COVERAGE study group.. Self-collected finger-prick blood for gene expression profiling: Unveiling early immune responses in mild COVID-19. 2026. iScience. 29. 2114593.

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Description

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COVERAGE France: A French national adaptative platform trial to evaluate outpatient treatments against COVID-19